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Fig. 2 | Parasites & Vectors

Fig. 2

From: Absence of Batf3 results in reduced liver pathology in mice infected with Schistosoma japonicum

Fig. 2

Parasite burden were observed at 9 weeks post S. japonicum infection in Batf3 −/− and B6 mice. Infection by S. japonicum results in an alleviated liver granulomatous inflammation in Batf3 −/−mice. Worm and egg burdens are similar in Batf3 −/− and B6 mice infected with S. japonicum. a Representative granulomas with a single egg from Batf3 −/− and B6 group. Liver sections were stained with HE and sirius red for microscopic examination. b Average area of single egg granulomas from Batf3 −/− and B6 group. Sizes of the granulomas were measured by computer-assisted morphometric analysis. c The average integrated optical density (AOD) in Batf3 −/− and B6 mice. Results of deposition of collagen fibers were analyzed using imageJ software. d Average number of worm couples recovered. e Average number of worms recovered. f Total number of eggs in the liver. g Average number of eggs per gram (EPG) in the liver. Results are representative of two independent experiments. Each bar represents the mean ± SEM from six mice per group. (*P < 0.05). Scale-bars: 50 μm

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