Fig. 4

Tc1 cell responses induced by Batf3-independent CD8α⁺ DCs. a A small amount of CD8α⁺ DCs was detected in the Batf3 ^−/− mouse schistosomiasis infection model.Percentages of CD11c⁺CD8a⁺cells analysed by FCM at 9 weeks post-infection. The upper right quadrant is the proportion of CD8α⁺ DCs cell subsets. b Expression of Irf8, PU.1, Id2, Nfil3 and Batf3genes of Batf3 ^−/− and B6 mice after S. japonicum infection. Expression of Irf8, PU.1, Id2, Nfil3 and Batf3 genes in the spleen were detected at 0, 3, 6 and 9 weeks post-infection by RT-PCR. (**P < 0.01, ***P < 0.001) Results are representative of two independent experiments. Data are presented as the mean ± SEM from six mice in each group