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Fig. 2 | Parasites & Vectors

Fig. 2

From: IL-32γ promotes the healing of murine cutaneous lesions caused by Leishmania braziliensis infection in contrast to Leishmania amazonensis

Fig. 2

IL-32 promotes the control of cutaneous infection caused by L. braziliensis, but not caused by L. amazonensis in an ear dermis model. WT and IL-32γTg mice were infected in the left ear with 1 × 105 L. amazonensis (IFLA/BR/67/PH8) or L. braziliensis (MHOM/BR/2003/IMG) promastigotes in the stationary phase of growth (6 days of culture). a Ear thickness was monitored weekly, and lesion size was determined by the difference between infected and uninfected ears. a L. amazonensis infection. b L. braziliensis infection. c Area under the curves is shown for each animal. d Ear parasite numbers were determined on week 3, 6 and 9 post-infection with L. amazonensis using limiting dilution assays. e Lymph node and spleen parasite numbers were determined on week 9 post-infection with L. amazonensis. f Ear parasite numbers were determined on week 3, 6 and 9 post-infection with L. braziliensis using limiting dilution assays. The results presented mean ± standard deviation (8 animals per group). *P < 0.05 (WT × IL-32γTg, Student’s t-test)

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