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Table 4 EC50 values and combination indexes of single drugs and drug combination - Ctenocephalides felis, coated glass assay

From: Synergy between dinotefuran and fipronil against the cat flea (Ctenocephalides felis): improved onset of action and residual speed of kill in adult cats

Drug or drug combinations EC50 (ppm) Combination index (CI)
Dinotefuran Fipronil Total amount of actives - Mean (95% confidence interval)
Dinotefuran 2.74 2.74 (1.95–3.53)
Fipronil 10.80 10.80 (10.44–11.16)
Dinotefuran + fipronil 2:1 1.08 0.54 1.63 (1.53–1.73) 0.44