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Table 4 EC50 values and combination indexes of single drugs and drug combination - Ctenocephalides felis, coated glass assay

From: Synergy between dinotefuran and fipronil against the cat flea (Ctenocephalides felis): improved onset of action and residual speed of kill in adult cats

Drug or drug combinations

EC50 (ppm)

Combination index (CI)

Dinotefuran

Fipronil

Total amount of actives - Mean (95% confidence interval)

Dinotefuran

2.74

2.74 (1.95–3.53)

Fipronil

10.80

10.80 (10.44–11.16)

Dinotefuran + fipronil 2:1

1.08

0.54

1.63 (1.53–1.73)

0.44