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Table 5 The curative efficacy of a combination of dinotefuran/fipronil administered topically on Day 0 following infestation of cats with Ctenocephalides felis on Day -1

From: Synergy between dinotefuran and fipronil against the cat flea (Ctenocephalides felis): improved onset of action and residual speed of kill in adult cats

Day 0 time point Variable Flea counts
Geometric mean Arithmetic mean
3 h Untreated (Group 1) 69.2 71.0
DF (Group 2) 1.8 2.0
Percentage efficacy 97.4 97.2
6 h Untreated (Group 1) 60.5 62.8
DF (Group 2) 0 0
Percentage efficacy 100 100
12 h Untreated (Group 1) 57.8 59.6
DF (Group 2) 0.1 0.1
Percentage efficacy 99.8 99.8
  1. Abbreviation: DF, dinotefuran/fipronil combination