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Table 6 Preventative efficacy of dinotefuran/fipronil administered topically to cats on day 0, against re-infestation with Ctenocephalides felis on days 7, 14, 21, 28, 35 and 42

From: Synergy between dinotefuran and fipronil against the cat flea (Ctenocephalides felis): improved onset of action and residual speed of kill in adult cats

Time point Criteria Mean flea counts on day (D)
D7 D14 D21 D28 D35 D42
GM AM GM AM GM AM GM AM GM AM GM AM
6 h Untreated 62.7 64.3 60.2 62.1 68.9 70.4 75.1 76.4 70.2 72.0 71.9 73.6
DF 0.6 0.9 0.5 0.8 1.9 2.8 4.3 7.0 15.2 23.9 26.6 33.6
Efficacy (%) 99.1 98.6 99.2 98.8 97.3 96.1 94.2 90.8 78.3 66.8 63.0 54.3
48 h Untreated 57.8 58.4 48.8 49.5 65.9 67.9 48.1 50.4 55.2 58.6 54.5 55.8
DF 0.0 0.0 0.1 0.3 0.4 0.9 0.1 0.1 1.4 3.0 2.6 3.9
Efficacy (%) 100 100 99.7 99.5 99.4 98.7 99.8 99.8 97.4 94.9 95.2 93.0
  1. Abbreviations: GM, geometric mean; AM, arithmetic mean; DF, dinotefuran/fipronil combination