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Table 6 Preventative efficacy of dinotefuran/fipronil administered topically to cats on day 0, against re-infestation with Ctenocephalides felis on days 7, 14, 21, 28, 35 and 42

From: Synergy between dinotefuran and fipronil against the cat flea (Ctenocephalides felis): improved onset of action and residual speed of kill in adult cats

Time point

Criteria

Mean flea counts on day (D)

D7

D14

D21

D28

D35

D42

GM

AM

GM

AM

GM

AM

GM

AM

GM

AM

GM

AM

6 h

Untreated

62.7

64.3

60.2

62.1

68.9

70.4

75.1

76.4

70.2

72.0

71.9

73.6

DF

0.6

0.9

0.5

0.8

1.9

2.8

4.3

7.0

15.2

23.9

26.6

33.6

Efficacy (%)

99.1

98.6

99.2

98.8

97.3

96.1

94.2

90.8

78.3

66.8

63.0

54.3

48 h

Untreated

57.8

58.4

48.8

49.5

65.9

67.9

48.1

50.4

55.2

58.6

54.5

55.8

DF

0.0

0.0

0.1

0.3

0.4

0.9

0.1

0.1

1.4

3.0

2.6

3.9

Efficacy (%)

100

100

99.7

99.5

99.4

98.7

99.8

99.8

97.4

94.9

95.2

93.0

  1. Abbreviations: GM, geometric mean; AM, arithmetic mean; DF, dinotefuran/fipronil combination