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Fig. 8 | Parasites & Vectors

Fig. 8

From: Molluscicidal activity and mechanism of toxicity of a novel salicylanilide ester derivative against Biomphalaria species

Fig. 8

Transmission electron microscope observations of hepatopancreas cell organelles of B. glabrata. The magnification times of the photos are as follows: a and d (×3900; scale-bars: 2 μm), g (×2850; scale-bars: 5 μm), b, e and h (×5800; scale-bars: 2 μm), and c, f and i (×7900; scale-bars: 1 μm). ac The normal ultrastructural features of B. glabrata hepatopancreas cells. Abundant rough endoplasmic reticulum (rER) and long oval or irregular nuclei (N) were observed in cells, as well as mitochondria (M) and circular secretion granules (G) in the cytoplasm. Clear nucleolus (Nu) and exiguous heterochromatin were distributed in the nucleus. df The ultrastructural alterations of hepatopancreas cells exposed to niclosamide included clumped heterochromatin in the nucleus (df), focal lysis of the nucleolus (e, large arrow), and polymorphic nuclei (f), as well as vacuolization of the mitochondria (e, small arrow), partially destroyed endoplasmic reticulum (E/F, moderate arrow) and degeneration of secretion granules. gi The ultrastructural alterations of hepatopancreas cells exposed to salicylanilidate. The endoplasmic reticulum was seriously damaged or showed obvious vacuolization in all three photos (gi). Both the nucleus and mitochondria (arrow) were swollen in (g), but the nucleolus was still clear. Lysosomes (L) appeared in g and h (small arrow). Other changes included marginalized heterochromatin (h), polymorphic nuclei (i) and degeneration of secretion granules (g)

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