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Table 1 Immune response in scabies

From: Host immune responses to the itch mite, Sarcoptes scabiei, in humans

  Ordinary scabies (OS) Crusted scabies (CS)
Skin cellular responses Mostly CD4+ T cells, eosinophils and macrophages [24] Mostly CD8+ T cells, increased γδ+ T cells, eosinophils and few macrophages [14, 24, 35, 88]
Blood cell responses T and B cells and T-cell subsets within normal ranges T and B cells and T-cell subsets within normal ranges. Increased γδ+ T cells, eosinophilia [24, 88]
Th1/Th2 responses Th1 mediated with increased production of Th1 cytokines IFN-γ, IL-2 and TNF-α [35, 46, 51]. Increased production of IL-10 [51] Th2 mediated with increased production of Th2 cytokines IL-4, IL-5 and IL-13 [14, 35, 46].
Increased production of Th17 cytokines IL-17, IL −23 [46, 88].
Decreased production of IL-10 [24, 35]
Systemic Ig responses Variable reports of elevated levels of total IgG, IgE, IgA and IgM. Increased levels of scabies-specific IgE, IgG and IgA [24, 35] Increased levels of total IgG, IgG1, IgG3, IgG4, IgE and IgA. Elevated levels of scabies specific IgG4, IgE and IgA [24, 35]