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Table 1 Antimicrobial profile of HlDFS1 and HlDFS2

From: Functional characterization of two defensins, HlDFS1 and HlDFS2, from the hard tick Haemaphysalis longicornis

Strain

HlDFS1

HlDFS2

MIC50 (μM)

MIC90 (μM)

MIC50 (μM)

MIC90 (μM)

Gram-positive bacteria

    

Bacillus pumilus (CMCC63202)

No effect

No effect

No effect

No effect

Staphylococcus aureus (CMCC26003)

10

50

50

> 50

Micrococcus luteus (CMCC28001)

5

10

1

1

Mycobacterium bovis

0.2

0.5

0.5

0.5

Gram-negative bacteria

    

Salmonella typhimurium (CVCC542)

No effect

No effect

No effect

No effect

Pseudomonas aeruginosa (CVCC2000)

No effect

No effect

No effect

No effect

Escherichia coli (CMCC44103)

5

5

1

1

Borrelia burgdorferi (297-GFP)

50

50

5

20

Fungi

    

Candida albicans (CAU0037)

50

> 50

No effect

No effect

  1. Abbreviations: MIC50 and MIC90: minimum inhibitory concentration required to inhibit the growth of 50% (MIC50) or 90% (MIC90) of organisms. Determination of MICs was performed at least three times in triplicates