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Table 1 Antimicrobial profile of HlDFS1 and HlDFS2

From: Functional characterization of two defensins, HlDFS1 and HlDFS2, from the hard tick Haemaphysalis longicornis

Strain HlDFS1 HlDFS2
MIC50 (μM) MIC90 (μM) MIC50 (μM) MIC90 (μM)
Gram-positive bacteria     
Bacillus pumilus (CMCC63202) No effect No effect No effect No effect
Staphylococcus aureus (CMCC26003) 10 50 50 > 50
Micrococcus luteus (CMCC28001) 5 10 1 1
Mycobacterium bovis 0.2 0.5 0.5 0.5
Gram-negative bacteria     
Salmonella typhimurium (CVCC542) No effect No effect No effect No effect
Pseudomonas aeruginosa (CVCC2000) No effect No effect No effect No effect
Escherichia coli (CMCC44103) 5 5 1 1
Borrelia burgdorferi (297-GFP) 50 50 5 20
Fungi     
Candida albicans (CAU0037) 50 > 50 No effect No effect
  1. Abbreviations: MIC50 and MIC90: minimum inhibitory concentration required to inhibit the growth of 50% (MIC50) or 90% (MIC90) of organisms. Determination of MICs was performed at least three times in triplicates