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Table 2 Antimicrobial activity of HlDFS1 and HlDFS2 against antibiotic resistant bacteria

From: Functional characterization of two defensins, HlDFS1 and HlDFS2, from the hard tick Haemaphysalis longicornis

Strain HlDFS1 HlDFS2
MIC50 (μM) MIC90 (μM) MIC50 (μM) MIC90 (μM)
Gram-positive bacteria     
Staphylococcus aureus (No. 570) 50 > 50 > 50 > 50
Staphylococcus epidermidis (No. 526) 20 50 20 50
Staphylococcus epidermidis (No. 527) 5 50 2 2
Staphylococcus epidermidis (No. 532) 50 > 50 No effect No effect
Gram-negative bacteria     
Acinetobacter baumannii (No. 531) 5 50 10 20
Acinetobacter baumannii (No. 546) 50 > 50 50 > 50
Enterobacter aerogenes (No. 516) 50 > 50 > 50 > 50
Escherichia coli (No. 572) > 50 > 50 50 > 50
Escherichia coli (No. 582) 50 > 50 > 50 > 50
Klebsiella pneumoniae (No. 570) No effect No effect No effect No effect
Klebsiella pneumoniae (No. 593) > 50 > 50 No effect No effect
  1. Abbreviations: MIC50 and MIC90: minimum inhibitory concentration required to inhibit the growth of 50% (MIC50) or 90% (MIC90) of organisms. Determination of MICs was performed at least three times in triplicates