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Table 2 Antimicrobial activity of HlDFS1 and HlDFS2 against antibiotic resistant bacteria

From: Functional characterization of two defensins, HlDFS1 and HlDFS2, from the hard tick Haemaphysalis longicornis

Strain

HlDFS1

HlDFS2

MIC50 (μM)

MIC90 (μM)

MIC50 (μM)

MIC90 (μM)

Gram-positive bacteria

    

Staphylococcus aureus (No. 570)

50

> 50

> 50

> 50

Staphylococcus epidermidis (No. 526)

20

50

20

50

Staphylococcus epidermidis (No. 527)

5

50

2

2

Staphylococcus epidermidis (No. 532)

50

> 50

No effect

No effect

Gram-negative bacteria

    

Acinetobacter baumannii (No. 531)

5

50

10

20

Acinetobacter baumannii (No. 546)

50

> 50

50

> 50

Enterobacter aerogenes (No. 516)

50

> 50

> 50

> 50

Escherichia coli (No. 572)

> 50

> 50

50

> 50

Escherichia coli (No. 582)

50

> 50

> 50

> 50

Klebsiella pneumoniae (No. 570)

No effect

No effect

No effect

No effect

Klebsiella pneumoniae (No. 593)

> 50

> 50

No effect

No effect

  1. Abbreviations: MIC50 and MIC90: minimum inhibitory concentration required to inhibit the growth of 50% (MIC50) or 90% (MIC90) of organisms. Determination of MICs was performed at least three times in triplicates