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Table 5 Target site resistance and detoxification mechanisms detected for An. gambiae and An. funestus populations

From: Review of the evolution of insecticide resistance in main malaria vectors in Cameroon from 1990 to 2017

Species Insecticide family Insecticides Resistance mechanisms  
    Target site Metabolic detoxification Reference
An. gambiae, An. coluzzii Organochlorines DDT L1014F & L1014S cyp6m2, cyp6p3, cyp6p4, cyp6z3, cyp9k1, gstd1-6, gstd1-4 [15, 16, 28, 50]
  Dieldrin RDLR   [3, 73, 74]
Carbamates Bendiocarb   cyp6z3, cyp6z1, cyp12f2, cyp6m3, cyp6p4 [52]
Pyrethroids Permethrin & deltamethrin L1014F & L1014S cyp6m2, cyp6p3, cyp6p4, cyp6z3, cyp9k1, gstd1-6, gstd1-4 [15, 16, 28, 30, 50]
An. arabiensis Organochlorines DDT L1014F   [29]
Pyrethroids Permethrin & deltamethrin L1014F cyp4g16, sod3b, gst1-2, sod3a, sod2, tpx4, cyp4h24, cyp6p3, cyp325c2, cyp6ag1 [12, 30, 51]
An. funestus Organochlorines DDT 119F-GSTe2 Overexpression of P450 Monooxygenase (suspected) [3, 14]
  Dieldrin 296S-RDL   [3, 14]
Carbamates Bendiocarb    
Pyrethroids Permethrin & deltamethrin   Overexpression of P450 Monooxygenase (suspected) [14]
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Parasites & Vectors

ISSN: 1756-3305

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