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Table 4 Histopathologic grading (Scores 0–3) of fixed perfused lung of cats on Day 510 post infection after L3 D. immitis infection

From: The progression of heartworm associated respiratory disease (HARD) in SPF cats 18 months after Dirofilaria immitis infection

Site Groupa Mean Score Standard Deviation Significanceb
Bronchus A 1.18 0.85  
B 0.97 0.80  
C 2.29 0.90 0.001
Bronchiole A 0.44 0.54  
B 0.50 0.54  
C 1.40 0.93 0.001
Alveolus/smooth muscle A 0.54 0.61  
B 0.26 0.48  
C 1.73 1.09 0.001
Arteriole A 0.80 0.83  
B 0.80 0.88  
C 2.18 0.96 0.001
Pulmonary artery A 0.50 0.54  
B 0.73 0.81  
C 2.34 0.84 0.001
  1. aGroup A (10): selamectin treatment initiated on Day 28 PI; Group B: (10) oral ivermectin treatment initiated Day 70 PI; Group C: infected untreated
  2. bGroup C (9) was significantly different than Groups A and Group B, which were not significantly different from each other