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Table 1 Concentrations of serum biomarkers evaluated throughout the adulticide therapy in heartworm-infected dogs treated according to 2014 AHS guidelines. See Fig. 1 for time point (T) indicated in this table

From: Evaluation of cardiopulmonary and inflammatory markers in dogs with heartworm infection during treatment with the 2014 American Heartworm Society recommended treatment protocol

Markers T-60 T0 T1 T7 T30 T31 T32 T39 T62 T92 T122 T182
cTnI I (median) .06 .07 .07 .04 .03# .03# .02# .02# .01# .02# .01# .01#
Min .05 .03 .04 .03 .02 .01 .01 .01 .01 .01 .01 .01
Max .12 .09 .12 .06 .04 .05 .05 .02 .02 .03 .03 .04
II (median) .19* .17* .16* .08*,# .05# .05# .06*,# .03# .02# .01# .03# .02#
Min .09 .07 .07 .03 .01 .03 .04 .01 .01 .01 .01 .01
Max .31 .21 .27 .13 .11 .13 .11 .11 .05 .02 .03 .03
III (median) .28* .26* .24*# .14*# .07*,# .07*# .06*# .03# .01# .03# .02# .01#
Min .09 .09 1.0 .03 .05 .05 .05 .01 .01 .01 .00 .01
Max .59 .31 .33 .21 .09 .09 .09 .04 .03 .04 .04 .03
D-dimer I (median) .05 .00 .10 .03 .00 .09# .13# .00 .00 .00 .00 .00
Min .00 .00 .05 .00 .00 .00 .00 .00 .00 .00 .00 .00
Max .10 .05 .11 .10 .10 .21 .22 .05 .05 .05 .00 .00
II (median) .19* .14* .05# .14* .08# .16 .00 .11* .00# .00# .00# .00#
Min .05 .09 .00 .12 .00 .15 .00 .00 .00 .00 .00 .00
Max .21 .16 .09 .17 .32 .24 .58 .19 .00 .09 .00 .00
III (median) .44* .38* .23* .08*# .00# .14# .15# .17# .00# .21# .06# .03#
Min .35 .12 .00 .00 .00 .00 .07 .05 .00 .00 .00 .00
Max 1.25 1.14 1.40 .30 .17 .18 .58 .38 .00 .27 .13 .14
CRP I (median) 4 1 3 31# 7 28# 7 30# 2 2 1 1
Min 1 0 2 21 0 17 2 19 0 0 0 0
Max 10 7 11 41 11 35 17 41 3 7 5 3
II (median) 17* 1 5 23 7 22 3 32 3 0# 1# 1#
Min 10 0 1 2 3 6 0 12 0 0 0 0
Max 32 10 11 45 19 39 11 50 28 10 5 2
III (median) 62* 39* 46* 78*# 36*# 45 56* 87*# 30*# 18*# 16*# 12*#
Min 33 35 18 54 24 23 34 40 14 0 0 2
Max 101 75 87 121 56 72 100 123 58 45 31 21
IL-6 I (median) 28 17 28 39 17 46 44 45 18 25 19 12
Min 9 12 11 23 5 5 29 17 9 15 5 8
Max 35 21 44 72 37 63 49 54 23 33 34 31
II (median) 65* 48* 57* 111*# 61* 64* 72* 69* 47*# 35# 35# 23#
Min 51 26 21 49 32 39 26 45 19 32 21 14
Max 94 67 123 250 86 83 102 102 54 62 45 27
III (median) 93* 41*# 41*# 192* 110* 90* 139*# 170*# 57*# 33# 26# 20#
Min 78 19 30 128 56 67 65 57 42 12 10 17
Max 135 57 90 250 250 250 250 250 98 56 66 31
  1. Abbreviations: cTnI cardiac troponin I, CRP C-reactive protein, IL-6 interleukin 6
  2. *P < 0.05 class I to class II and III
  3. # P < 0.05 baseline value (T-60) to each time point