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Table 3 Efficacy of oral moxidectin (3 μg/kg) in preventing the development of selected isolates of D. immitis

From: Efficacy of oral moxidectin against susceptible and resistant isolates of Dirofilaria immitis in dogs

       Adult D. immitis worm counts1  
Study D. immitis isolate Treatment2 Dosage (μg/kg) Days of Tx No. Dogs with worms Worm count range Geometric mean3 % reduction Isolate phenotype
1 Michigan Placebo NA 0 8 of 8 18–32 24.4a NA  
1 Michigan Moxidectin 3 0 0 of 8 0 0.0b 100 Susceptible
2 MP3 Placebo NA 0 8 of 8 21–42 35.1a NA  
2 MP3 Moxidectin 3 0 0 of 8 0 0.0b 100 Susceptible
3 ZoeKY Placebo NA 0 6 of 6 16–36 26.2a NA  
3 ZoeKY Moxidectin 3 0 0 of 6 0 0 b 100 Susceptible
4 GCFL Placebo NA 0 3 of 3 21–35 28.4a NA  
4 GCF Moxidectin 3 0 0 of 3 0 0b 100 Susceptible
5 ZoeAL Placebo NA 0 6 of 6 26–47 33.0a NA  
5 ZoeAL Moxidectin 3 0 0 of 6 0 0b 100 Susceptible
6 JYD-34 Placebo NA 0, 30, 60 8 of 8 29–43 35.9a NA  
6 JYD-34 Moxidectin 3 0 8 of 8 20–39 29.1b 19.0 Resistant
6 JYD-34 Moxidectin 3 0, 30, 60 8 of 8 7–36 20.0b 44.4 Resistant
7 ZoeMO Placebo NA 0 6 of 6 15–32 21.2a NA  
7 ZoeMO Moxidectin 3 0 6 of 6 2–7 5.5b 82.7 Resistant
8 ZoeLA Placebo NA 0 6 of 6 22–38 32.2a NA  
8 ZoeLA Moxidectin 3 0 6 of 6 11–26 14.8b 54.0 Resistant
9 AMAL Placebo NA 0 3 of 3 43–48 45.0a NA  
9 AMAL Moxidectin 3 0 3 of 3 12–25 17.3b 61.6 Resistant
  1. 1Dogs inoculated with 50 infective larvae (L3) on Days −28 to −30
  2. 2Moxidectin administered as ProHeart® tablets shaved to deliver the exact dose
  3. 3Within a study, means with different superscripts are significantly different (P < 0.05)
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