Table 1 Mean microfilariae (MF) counts (per mL) after treatment with a single SC dose of either PH 6 (0.17 mg/kg) or PH 12 (0.5 mg/kg) or a single oral treatment with moxidectin (0.25 mg/kg) on Day 0
Day of Study | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Test Group | 0 | 1 | 3 | 7 | 14 | 21 | 28 | 42 | 56 | 84 | 112 | 140 | 168 |
Control | 15,000.0 | 18,308.3 | 16,488.3 | 12,566.7 | 14,756.7 | 19,400.0 | 20,383.3 | 15,830.0 | 16,381.7 | 20,816.7 | 23,133.3 | 18,633.3 | 26,633.3 |
PH 6 | 13,916.7 | 16,531.7 | 11,796.7 | 3141.7 | 4358.3 | 4318.3 | 2755.0 | 1530.0* | 1421.7 | 675.0* | 780.0* | 203.7* | 176.8* |
PH 12 | 11,520.0 | 14,480.0 | 6330.0 | 2656.0 | 2486.0 | 2918.0 | 1786.0 | 916.2* | 997.0* | 646.0* | NA | NA | NA |
Oral Moxidectin (0.25 mg/kg) | 12,033.3 | 2501.7 | 3138.3 | 3213.3 | 2830.0 | 3833.3 | 3333.3 | 2040.0 | 2983.3 | 1531.7 | NA | NA | NA |