Table 2 Percentage reduction in mean microfilaria (MF) counts (compared with control) after treatment with a single SC dose of either PH 6 (0.17 mg/kg) or PH 12 (0.5 mg/kg) or a single oral treatment with moxidectin (0.25 mg/kg) on Day 0
Day of Study | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Test Group | 0 | 1 | 3 | 7 | 14 | 21 | 28 | 42 | 56 | 84 | 112 | 140 | 168 |
PH 6 | 7.2 | 9.7 | 28.5 | 75.0 | 70.5 | 77.7 | 86.5 | 90.3 | 91.3 | 96.8 | 96.6 | 98.9 | 99.3 |
PH 12 | 23.2 | 20.9 | 61.6 | 78.9 | 83.2 | 85.0 | 91.2 | 94.2 | 93.9 | 96.9 | ND | ND | ND |
Oral Moxidectin (0.25 mg/kg) | 19.8 | 86.3 | 81.0 | 74.4 | 80.8 | 80.2 | 83.6 | 87.1 | 81.8 | 92.6 | ND | ND | ND |