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Table 2 Inhibition of microfilariae motility by ivermectin in vitro

From: Does evaluation of in vitro microfilarial motility reflect the resistance status of Dirofilaria immitis isolates to macrocyclic lactones?

Strain IC50 μM IVM Resistance status
Missouri 8.4 ± 1.6 susceptible
MP3 5.8 ± 1.3 ‘less susceptible’
JYD N/A resistant
Yazoo 2013–1 3.5 ± 1.6 resistant
Yazoo 2013–2.1 N/A resistant
Metairie 8.1 ± 1.3 resistant
  1. Microfilariae of the isolates were isolated and incubated with various concentrations of ivermectin for 24 h at 37 °C in a 5% CO2 atmosphere. Motility was assessed using the ‘Worminator’ as described and the IC50 calculated using Prism 6