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Table 1 Efficacy data for various trials reported in Snyder et al. [10] and [11] using the MP3 strain of Dirofilaria immitis and treatment using milbemycin oxime (0.5–0.75 mg/kg) and spinosad (30–45 mg/kg)

From: A statistical approach for evaluating the effectiveness of heartworm preventive drugs: what does 100% efficacy really mean?

Treatment regimena,b Number of worms recovered in treated dogs Geometric mean Model-based mean Model-based 95% CI
30 daysa 1 99.8 99.8 99.2, 100
30 daysb 5 98.99 98.51 97.36, 99.44
45 daysb 5 98.87 98.52 97.37, 99.45
30 and 60 daysb 1 99.63 99.51 98.59, 100
15 and 45 daysb 0 100 100 N/A
30, 60 and 90 daysb 0 100 100 N/A
  1. One, two or three doses of drug were administered either 30, 45, 30/60, 15/45, or 30/60/90 days post inoculation with infective L3. Model based mean and 95% confidence intervals (CI) were calculated using the parametric bootstrap model described in the text
  2. aData from Snyder et al., [10]
  3. bData from Snyder et al., [11]