Skip to main content

Table 1 Minocycline and doxycycline pharmacokinetics in dogs

From: Considerations for using minocycline vs doxycycline for treatment of canine heartworm disease

Parameter Doxycycline Minocycline
Half-life (T-½) (hr) 12.6 (± 11) 5.18 (± 1.02)
VD/F (L/kg) 1.67 (± 0.81) 2.3 (± 0.59)
CL/F (L/kg/h) 0.13 (± 0.06) 0.28 (± 0.08)
Absorption (F) 61% (± 8) 50.3% (± 20.8)
Protein binding % 91–92% 65.8% (in vitro)
50% (in vivo)
  1. VD/F volume of distribution per fraction absorbed, CL/F clearance per fraction absorbed, F fraction absorbed. These parameters are presented as a weighted mean value to account for differences in the number of subjects in each study, as well as between-study and within-study variation [11,12,13,14,15]