From: Considerations for using minocycline vs doxycycline for treatment of canine heartworm disease
Parameter | Doxycycline | Minocycline |
---|---|---|
Half-life (T-½) (hr) | 12.6 (± 11) | 5.18 (± 1.02) |
VD/F (L/kg) | 1.67 (± 0.81) | 2.3 (± 0.59) |
CL/F (L/kg/h) | 0.13 (± 0.06) | 0.28 (± 0.08) |
Absorption (F) | 61% (± 8) | 50.3% (± 20.8) |
Protein binding % | 91–92% | 65.8% (in vitro) 50% (in vivo) |