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Table 2 Antibacterial interpretive categories (breakpoints) for tetracycline antibacterial agents in dogs from CLSI [17]

From: Considerations for using minocycline vs doxycycline for treatment of canine heartworm disease

Drug Susceptible Intermediate Resistant
Doxycycline ≤ 0.12 μg/mL 0.25 μg/mL ≥ 0.5 μg/mL
Tetracycline ≤0.25 μg/mL 0.5 μg/mL ≥1.0 μg/mL
Minocycline ≤0.5 μg/mL 1.0 μg/mL ≥2.0 μg/mL