Skip to main content

Table 3 Doxycycline and minocycline exposure in mice and humans after administration of standard doses in order to produce similar exposure relationships (AUC) in mice

From: Considerations for using minocycline vs doxycycline for treatment of canine heartworm disease

  100 mg dose
Human
200 mg dose
Human
Doxycycline Minocycline Doxycycline Minocycline
AUC
μg·hr./mL
28.4 17.7 56.9 35.4
  Mouse 25 mg/kg
once daily
Mouse 25 mg/kg
twice daily*
Doxycycline Minocycline Doxycycline Minocycline
AUC
μg·hr./mL
22.8 7.8 40.6 14.9
Wolbachia reduction 66.3% 85% 90.35% 99.5%
  1. AUC area under the curve for doxycycline or minocycline exposure after standard dosages. *There were no significant changes in the level of Wolbachia depletion when comparing dose escalations between 25 and 80 mg/kg twice daily. Data from Sharma, et al. [9]