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Table 4 Probability of target attainment (PTA %) for doxycycline and minocycline at doses ranging from 0.625 to 10 mg/kg administered orally every 12 h to dogs

From: Considerations for using minocycline vs doxycycline for treatment of canine heartworm disease

Drug and AUC Target (μg·hr./mL) Dose (mg/kg, twice daily, oral)  
0.625 1.25 1.875 2.5 3.75 5 6.25 7.5 8.75 10
Doxycycline 22.8 4.1 45 79.37 91.5 99.5 99.9 100 100 100 100
Doxycycline 40.6 0.08 6.5 28 53.7 85 96.1 99.63 99.84 100 100
Minocycline 7.8 4 72 97.05 99.6 100 100 100 100 100 100
Minocycline 15 0 4.6 39.3 76 98.3 99.78 100 100 100 100