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Table 4 Histopathologic grading (scoring 0–3) and lumen to wall ratio of fixed perfused in cat lung

From: Heartworm-associated respiratory disease (HARD) induced by immature adult Dirofilaria immitis in cats

Site Groupa Lesion Score Significanceb
Bronchus A 1.40  
B 1.89 0.010
C 2.40 0.003
Bronchiole A 1.65  
B 1.89  
C 2.50 0.009
Alveolus/Smooth Muscle A 1.40  
B 2.11 0.050
C 2.60 0.001
Arteriole A 1.75  
B 2.39 0.002
C 2.70 0.002
Pulmonary Artery A 1.20  
B 2.22 0.001
C 2.60 0.001
Bronchiole Lumen to Wall Ratioc A 1.416  
B 1.016 0.001
C 1.080 0.001
Pulmonary Arteriole Lumen to Wall ratioc A 0.332  
B 0.528  
C 1.187 0.001
  1. aTreatment groups: Group A, selamectin topical; Group B, oral ivermectin initiated on Day 70 PI; Group C, infected, no treatment
  2. bSignificance difference (ANOVA p > 0.05) noted between groups for each variable examined, and pairwise comparison (Holm-Sidak) significance in table notates differences between group B or C compared to group A
  3. cLumen to wall ratio is morphometric measure of area of lumen compared to area of wall of at least 5 bronchioles and 5 arterioles from each cat. Group B was not significantly different from Group C for any variable