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Fig. 1 | Parasites & Vectors

Fig. 1

From: Tyrosine kinase 4 is involved in the reproduction of the platyhelminth parasite Schistosoma japonicum

Fig. 1

Schistosoma japonicum TK4 belongs to the Syk kinase family. a Structure of the TK4 domain of S. japonicum. The tandem SH2 domain is located at the N-terminus of SjTK4, whereas the catalytic tyrosine kinase domain is located at the C-terminus. They are joined together by a linker region. The numbers in the figure represent the respective sequence coordinates for SjTK4 for each domain. b Comparison of amino acid sequences in S. japonicum TK4 (SjTK4, APD26308.1) with other organisms: S. mansoni (SmTK4, CAD13249.1), Mus musculus (mouse Syk, AAA87462.1), Rattus norvegicus (rat Syk, NP_036890.1), Homo sapiens (human Syk, AAH01645.1), and Sus scrofa (pig Syk, NP_001098422.1). The hallmark domains are marked above the alignment, positional information refer to SjTK4. The two red boxes outline the two SH2 domains (5′ SH2 position 21–140, 120aa; 3′ SH2 position, 168–279, 112 aa) and the blue box outlines the TK domain (position 847–1144, 298 aa). The green box delineates a conserved the protein kinase ATP binding domain (position 855–881, 27 aa)

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