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Fig. 1 | Parasites & Vectors

Fig. 1

From: Structural and functional characterization of the divergent Entamoeba Src using Src inhibitor-1

Fig. 1

EhSrc is highly divergent from its closest homologues. a Alignment of the conserved domain among EhSrc (EAL46348.1), EiSrc (XP_004258856.1) and human Src (NP_938033). Identical amino acid residues are in dark gray and similar amino acid residues in light gray. b Phylogenetic tree of Src proteins of E. histolytica, E. invadens, Homo sapiens, Mus musculus and C. elegans. EhSrc protein of E. histolytica shows the highest homology with the Src protein of E. invadens, and these two proteins are poorly related with Src proteins from mammals as well as the nematode C. elegans. c Structural domains of typical Src and EhSrc proteins from E. histolytica and E. invadens are shown. The typical Src is composed of an amino-terminal myristoylation sequence (M), a unique region (U), Src-homology-2 (SH2) and SH3 protein-interaction domains; the Src of Entamoeba lacks these domains with the exception of the kinase domain

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