From: The novel isoxazoline ectoparasiticide lotilaner (Credelio™): a non-competitive antagonist specific to invertebrates γ-aminobutyric acid-gated chloride channels (GABACls)
Receptor
Agonist
EC50 (μM)
nH
N
DmS-GABA
GABA
10.52 ± 0.70
1.57 ± 0.15
6
DmR2-GABA
12.43 ± 0.54
1.51 ± 0.09
7
Ls-GABA1
392.54 ± 11.05
1.35 ± 0.04
20
Rm-GABA
49.96 ± 0.76
2.27 ± 0.19
10
Cl-GABAA α1β2γ2
1.80 ± 0.14
1.31 ± 0.12
12