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Table 1 GABACl receptors response profiles. EC50 in μM ± SEM obtained with the natural agonist GABA

From: The novel isoxazoline ectoparasiticide lotilaner (Credelio™): a non-competitive antagonist specific to invertebrates γ-aminobutyric acid-gated chloride channels (GABACls)

Receptor

Agonist

EC50 (μM)

nH

N

DmS-GABA

GABA

10.52 ± 0.70

1.57 ± 0.15

6

DmR2-GABA

GABA

12.43 ± 0.54

1.51 ± 0.09

7

Ls-GABA1

GABA

392.54 ± 11.05

1.35 ± 0.04

20

Rm-GABA

GABA

49.96 ± 0.76

2.27 ± 0.19

10

Cl-GABAA α1β2γ2

GABA

1.80 ± 0.14

1.31 ± 0.12

12

  1. Abbreviations: Dm, Drosophila melanogaster; Ls, Lepeophtheirus salmonis; Rm, Rhipicephalus microplus; Cl, Canis lupus familiaris. The Hill coefficient (nH) is indicated as well as the number of oocytes evaluated (N)