Table 2 GABACl receptors response profiles to antagonists. IC50 in nM ± SEM obtained with a variety of compounds
Receptor | Antagonist | IC50 (nM) | nH | N |
|---|---|---|---|---|
DmS-GABA | Dieldrin | 4170 ± 920 | -0.45 ± 0.05 | 9 |
DmS-GABA | Fipronil | 27.58 ± 1.71 | -0.85 ± 0.04 | 8 |
DmS-GABA | Lotilaner | 23.84 ± 1.87 | -0.64 ± 0.03 | 16 |
DmS-GABA | AHC-2229544 | 959.47 ± 268.44 | -0.30 ± 0.03 | 8 |
DmR2-GABA | Dieldrin | > 10,000 | -0.15 ± 0.03 | 6 |
DmR2-GABA | Fipronil | 230.32 ± 27.29 | -0.57 ± 0.04 | 7 |
DmR2-GABA | Lotilaner | 38.25 ± 3.75 | -0.62 ± 0.04 | 7 |
Ls-GABA1 | Fipronil | 164.85 ± 11.80 | -0.78 ± 0.04 | 12 |
Ls-GABA1 | Lotilaner | 52.40 ± 4.54 | -0.75 ± 0.04 | 8 |
Rm-GABA | Fipronil | 25.56 ± 2.25 | -0.56 ± 0.03 | 6 |
Rm-GABA | Lotilaner | 36.79 ± 4.39 | -0.47 ± 0.03 | 8 |
Cl-GABAA α1β2γ2 | Lotilaner | > 10,000 | -0.09 ± 0.02 | 7 |