Two randomized, controlled studies to assess the efficacy and safety of lotilaner (Credelio™) in preventing Dermacentor reticulatus transmission of Babesia canis to dogs

Table 3 Summary of assessments for Babesia canis infection

Test	Test day	Cumulative proportion positive		Efficacy (%)	Comparison
Test	Test day	Control	Lotilaner
Blood smear	2	8/8	0/8	100	χ ² ₍₁₎ = 16, P = 0.0002
Blood smear	14	15/16	0/8	100	χ ² ₍₁₎ = 20, P < 0.0001
Study 1	28	15/23	0/8	100	χ ² ₍₁₎ = 10.11, P = 0.0024
Study 2	28	6/6	0/6	100	χ ² ₍₁₎ = 12, P = 0.0022
IFA	2	8/8	0/8	100	χ ² ₍₁₎ = 16, P = 0.0002
IFA	14	15/16	0/8	100	χ ² ₍₁₎ = 20, P < 0.0001
Study 1	28	15/23	0/8	100	χ ² ₍₁₎ = 10.11, P = 0.0024
Study 2	28	6/6	0/6	100	χ ² ₍₁₎ = 12, P = 0.0022
PCR	2	8/8	0/8	100	χ ² ₍₁₎ = 16, P = 0.0002
PCR	14	15/16	0/8	100	χ ² ₍₁₎ = 20, P < 0.0001
Study 1	28	15/23	0/8	100	χ ² ₍₁₎ = 10.11, P = 0.0024
Study 2	28	6/6	0/6	100	χ ² ₍₁₎ = 12, P = 0.0022

Abbreviations: IFA immunofluorescence assay, PCR polymerase chain reaction

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