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Table 1 Effect of different feeding regimens on bioavailability: statistical comparisons (Study 1)

From: The intravenous and oral pharmacokinetics of lotilaner in dogs

Treatment groups Ratioa (first/second) 90% CI t-value P-valueb
First Second     
Fed 30 min prior Fed at dose 1.137 0.820–1.576 t (20) = 0.68 0.5052
Fed 30 min prior Fed 1/3 of ration 1.252 0.904–1.735 t (20) = 1.19 0.2484
Fed 30 min prior Fed 30 min after 1.029 0.743–1.426 t (20) = 0.15 0.8799
Fed 30 min prior Fasted 2.250 1.624–3.118 t (20) = 4.29 0.0004
Fed at dose Fed 1/3 of ration 1.101 0.795–1.526 t (20) = 0.51 0.6154
Fed at dose Fed 30 min after 0.905 0.653–1.255 t (20) = -0.53 0.6050
Fed at dose Fasted 1.979 1.428–2.742 t (20) = 3.61 0.0018
Fed 1/3 of ration Fed 30 min after 0.822 0.593–1.139 t (20) = -1.04 0.3126
Fed 1/3 of ration Fasted 1.797 1.297–2.490 t (20) = 3.10 0.0057
Fed 30 min after Fasted 2.186 1.577–3.029 t (20) = 4.13 0.0005
  1. aRatio of bioavailabilities i.e. ratio of AUClast
  2. b P-values in bold denote significance