The intravenous and oral pharmacokinetics of lotilaner in dogs

Parasites & Vectors

Table 1 Effect of different feeding regimens on bioavailability: statistical comparisons (Study 1)

Treatment groups		Ratio^a (first/second)	90% CI	t-value	P-value^b
First	Second
Fed 30 min prior	Fed at dose	1.137	0.820–1.576	t ₍₂₀₎ = 0.68	0.5052
Fed 30 min prior	Fed 1/3 of ration	1.252	0.904–1.735	t ₍₂₀₎ = 1.19	0.2484
Fed 30 min prior	Fed 30 min after	1.029	0.743–1.426	t ₍₂₀₎ = 0.15	0.8799
Fed 30 min prior	Fasted	2.250	1.624–3.118	t ₍₂₀₎ = 4.29	0.0004
Fed at dose	Fed 1/3 of ration	1.101	0.795–1.526	t ₍₂₀₎ = 0.51	0.6154
Fed at dose	Fed 30 min after	0.905	0.653–1.255	t ₍₂₀₎ = -0.53	0.6050
Fed at dose	Fasted	1.979	1.428–2.742	t ₍₂₀₎ = 3.61	0.0018
Fed 1/3 of ration	Fed 30 min after	0.822	0.593–1.139	t ₍₂₀₎ = -1.04	0.3126
Fed 1/3 of ration	Fasted	1.797	1.297–2.490	t ₍₂₀₎ = 3.10	0.0057
Fed 30 min after	Fasted	2.186	1.577–3.029	t ₍₂₀₎ = 4.13	0.0005

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