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Table 1 Geometric (arithmetic) mean counts of live Dermacentor variabilis ticks

From: Laboratory evaluations of the immediate and sustained efficacy of lotilaner (Credelio™) against four common species of ticks affecting dogs in North America

  Day Untreated control Lotilaner Comparison
Mean Range Mean Range Geometric (arithmetic) mean efficacy (%)  
Study 1 2 33.6 (35.0) 22–48 0.0 (0.0) 0–0 100 (100) t (7) = 32.0, P < 0.0001
9 20.8 (23.0) 11–42 0.0 (0.0) 0–0 100 (100) t (7) = 18.7, P < 0.0001
16 20.0 (24.0) 5–44 0.1 (0.1) 0–1 99.5 (99.5) t (7) = 11.8, P < 0.0001
23 21.5 (24.3) 9–46 0.0 (0.0) 0–0 100 (100) t (7) = 16.7, P < 0.0001
30 12.7 (18.3) 0–38 0.1 (0.1) 0–1 99.3 (99.3) t (7) = 6.2, P = 0.0004
37 14.5 (19.6) 2–42 0.3 (0.5) 0–3 98.0 (97.5) t (7) = 7.2, P = 0.0002
Study 2 2 24.7 (25.0) 18–30 0.0 (0.0) 0–0 100 (100) t (14) = 53.5, P < 0.0001
9 7.1 (9.0) 3–23 0.0 (0.0) 0–0 na na
16 20.3 (21.9) 10–35 0.0 (0.0) 0–0 100 (100) t (13) = 24.0, P < 0.0001
23 29.4 (30.1) 22–41 0.0 (0.0) 0–0 100 (100) t (13) = 42.5, P < 0.0001
30 21.9 (22.3) 15–28 0.1 (0.1) 0–1 99.6 (99.4) t (14) = 27.6, P < 0.0001
37 29.6 (30.5) 17–40 0.0 (0.0) 0–0 100 (100) t (13) = 39.5, P < 0.0001
Study 3 2 16.6 (17.6) 11–36 0.0 (0.0) 0–0 100 (100) t (7) = 23.6, P < 0.0001
9 14.2 (20.6) 0–41 0.0 (0.0) 0–0 100 (100) t (7) = 6.5, P = 0.0003
16 21.3 (22.1) 13–33 0.0 (0.0) 0–0 100 (100) t (7) = 30.8, P < 0.0001
23 26.8 (27.8) 18–41 0.0 (0.0) 0–0 100 (100) t (7) = 34.5, P < 0.0001
30 31.8 (32.1) 25–39 0.0 (0.0) 0–0 100 (100) t (7) = 70.1, P < 0.0001
37 19.2 (21.3) 9–36 0.0 (0.0) 0–0 100 (100) t (7) = 17.7, P < 0.0001
  1. Abbreviation: na not applicable because of insufficient infestations in control dogs