Laboratory evaluations of the immediate and sustained efficacy of lotilaner (Credelio™) against four common species of ticks affecting dogs in North America

Table 1 Geometric (arithmetic) mean counts of live Dermacentor variabilis ticks

	Day	Untreated control		Lotilaner			Comparison
	Day	Mean	Range	Mean	Range	Geometric (arithmetic) mean efficacy (%)
Study 1	2	33.6 (35.0)	22–48	0.0 (0.0)	0–0	100 (100)	t ₍₇₎ = 32.0, P < 0.0001
	9	20.8 (23.0)	11–42	0.0 (0.0)	0–0	100 (100)	t ₍₇₎ = 18.7, P < 0.0001
	16	20.0 (24.0)	5–44	0.1 (0.1)	0–1	99.5 (99.5)	t ₍₇₎ = 11.8, P < 0.0001
	23	21.5 (24.3)	9–46	0.0 (0.0)	0–0	100 (100)	t ₍₇₎ = 16.7, P < 0.0001
	30	12.7 (18.3)	0–38	0.1 (0.1)	0–1	99.3 (99.3)	t ₍₇₎ = 6.2, P = 0.0004
	37	14.5 (19.6)	2–42	0.3 (0.5)	0–3	98.0 (97.5)	t ₍₇₎ = 7.2, P = 0.0002
Study 2	2	24.7 (25.0)	18–30	0.0 (0.0)	0–0	100 (100)	t ₍₁₄₎ = 53.5, P < 0.0001
	9	7.1 (9.0)	3–23	0.0 (0.0)	0–0	na	na
	16	20.3 (21.9)	10–35	0.0 (0.0)	0–0	100 (100)	t ₍₁₃₎ = 24.0, P < 0.0001
	23	29.4 (30.1)	22–41	0.0 (0.0)	0–0	100 (100)	t ₍₁₃₎ = 42.5, P < 0.0001
	30	21.9 (22.3)	15–28	0.1 (0.1)	0–1	99.6 (99.4)	t ₍₁₄₎ = 27.6, P < 0.0001
	37	29.6 (30.5)	17–40	0.0 (0.0)	0–0	100 (100)	t ₍₁₃₎ = 39.5, P < 0.0001
Study 3	2	16.6 (17.6)	11–36	0.0 (0.0)	0–0	100 (100)	t ₍₇₎ = 23.6, P < 0.0001
	9	14.2 (20.6)	0–41	0.0 (0.0)	0–0	100 (100)	t ₍₇₎ = 6.5, P = 0.0003
	16	21.3 (22.1)	13–33	0.0 (0.0)	0–0	100 (100)	t ₍₇₎ = 30.8, P < 0.0001
	23	26.8 (27.8)	18–41	0.0 (0.0)	0–0	100 (100)	t ₍₇₎ = 34.5, P < 0.0001
	30	31.8 (32.1)	25–39	0.0 (0.0)	0–0	100 (100)	t ₍₇₎ = 70.1, P < 0.0001
	37	19.2 (21.3)	9–36	0.0 (0.0)	0–0	100 (100)	t ₍₇₎ = 17.7, P < 0.0001

Abbreviation: na not applicable because of insufficient infestations in control dogs

ISSN: 1756-3305