Laboratory evaluations of the immediate and sustained efficacy of lotilaner (Credelio™) against four common species of ticks affecting dogs in North America

Table 2 Geometric (arithmetic) mean counts of live Rhipicephalus sanguineus ticks

	Day	Untreated control		Lotilaner			Comparison
	Day	Mean	Range	Mean	Range	Geometric (arithmetic) mean efficacy (%)
Study 2	2	25.5 (27.6)	7–36	0.0 (0.0)	0–0	100 (100)	t ₍₁₃₎ = 19.1, P < 0.0001
	9	25.1 (26.0)	15–40	0.0 (0.0)	0–0	100 (100)	t ₍₁₄₎ = 32.0, P < 0.0001
	16	22.9 (24.5)	9–36	0.1 (0.3)	0–2	99.4 (99.0)	t ₍₁₄₎ = 15.1, P < 0.0001
	23	28.6 (29.9)	19–47	0.1 (0.1)	0–1	99.7 (99.6)	t ₍₁₄₎ = 23.9, P < 0.0001
	30	21.9 (23.4)	10–35	0.1 (0.1)	0–1	99.6 (99.5)	t ₍₁₄₎ = 18.7, P < 0.0001
	37	26.1 (28.1)	13–45	0.0 (0.0)	0–0	100 (100)	t ₍₁₃₎ = 23.3, P < 0.0001
Study 3	2	5.2 (6.5)	2–20	0.0 (0.0)	0–0	na	na
	9	14.3 (16.0)	4–27	0.1 (0.1)	0–1	99.4 (99.2)	t ₍₇₎ = 12.7, P < 0.0001
	16	29.5 (31.0)	14–43	0.0 (0.0)	0–0	100 (100)	t ₍₇₎ = 27.8, P < 0.0001
	23	26.5 (27.8)	17–42	0.0 (0.0)	0–0	100 (100)	t ₍₇₎ = 29.2, P < 0.0001
	30	19.6 (20.4)	12–31	0.0 (0.0)	0–0	100 (100)	t ₍₇₎ = 28.4, P < 0.0001
	37	14.8 (15.3)	10–25	0.0 (0.0)	0–0	100 (100)	t ₍₇₎ = 31.5, P < 0.0001
Study 4	2	34.2 (35.4)	17–45	0.0 (0.0)	0–0	100 (100)	t ₍₄₎ = 37, P < 0.0001
	9	33.6 (34.4)	24–43	0.0 (0.0)	0–0	100 (100)	t ₍₄₎ = 49.6, P < 0.0001
	16	30.7 (31.4)	19–42	0.0 (0.0)	0–0	100 (100)	t ₍₄₎ = 42.8, P < 0.0001
	23	29.9 (30.5)	20–37	0.0 (0.0)	0–0	100 (100)	t ₍₄₎ = 51.9, P < 0.0001
	30	28.4 (29.5)	16–39	0.0 (0.0)	0–0	100 (100)	t ₍₄₎ = 36.2, P < 0.0001
	37	27.2 (28.3)	15–37	0.1 (0.1)	0–1	99.7 (99.6)	t ₍₄₎ = 33.5, P < 0.0001

Abbreviation: na not applicable because of insufficient infestations in control dogs

ISSN: 1756-3305