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Table 2 Geometric (arithmetic) mean counts of live Rhipicephalus sanguineus ticks

From: Laboratory evaluations of the immediate and sustained efficacy of lotilaner (Credelio™) against four common species of ticks affecting dogs in North America

  Day Untreated control Lotilaner Comparison
Mean Range Mean Range Geometric (arithmetic) mean efficacy (%)  
Study 2 2 25.5 (27.6) 7–36 0.0 (0.0) 0–0 100 (100) t (13) = 19.1, P < 0.0001
9 25.1 (26.0) 15–40 0.0 (0.0) 0–0 100 (100) t (14) = 32.0, P < 0.0001
16 22.9 (24.5) 9–36 0.1 (0.3) 0–2 99.4 (99.0) t (14) = 15.1, P < 0.0001
23 28.6 (29.9) 19–47 0.1 (0.1) 0–1 99.7 (99.6) t (14) = 23.9, P < 0.0001
30 21.9 (23.4) 10–35 0.1 (0.1) 0–1 99.6 (99.5) t (14) = 18.7, P < 0.0001
37 26.1 (28.1) 13–45 0.0 (0.0) 0–0 100 (100) t (13) = 23.3, P < 0.0001
Study 3 2 5.2 (6.5) 2–20 0.0 (0.0) 0–0 na na
9 14.3 (16.0) 4–27 0.1 (0.1) 0–1 99.4 (99.2) t (7) = 12.7, P < 0.0001
16 29.5 (31.0) 14–43 0.0 (0.0) 0–0 100 (100) t (7) = 27.8, P < 0.0001
23 26.5 (27.8) 17–42 0.0 (0.0) 0–0 100 (100) t (7) = 29.2, P < 0.0001
30 19.6 (20.4) 12–31 0.0 (0.0) 0–0 100 (100) t (7) = 28.4, P < 0.0001
37 14.8 (15.3) 10–25 0.0 (0.0) 0–0 100 (100) t (7) = 31.5, P < 0.0001
Study 4 2 34.2 (35.4) 17–45 0.0 (0.0) 0–0 100 (100) t (4) = 37, P < 0.0001
9 33.6 (34.4) 24–43 0.0 (0.0) 0–0 100 (100) t (4) = 49.6, P < 0.0001
16 30.7 (31.4) 19–42 0.0 (0.0) 0–0 100 (100) t (4) = 42.8, P < 0.0001
23 29.9 (30.5) 20–37 0.0 (0.0) 0–0 100 (100) t (4) = 51.9, P < 0.0001
30 28.4 (29.5) 16–39 0.0 (0.0) 0–0 100 (100) t (4) = 36.2, P < 0.0001
37 27.2 (28.3) 15–37 0.1 (0.1) 0–1 99.7 (99.6) t (4) = 33.5, P < 0.0001
  1. Abbreviation: na not applicable because of insufficient infestations in control dogs