Laboratory evaluations of the immediate and sustained efficacy of lotilaner (Credelio™) against four common species of ticks affecting dogs in North America

Table 4 Geometric (arithmetic) mean counts of live Ixodes scapularis ticks

	Day	Untreated control		Lotilaner			Comparison
	Day	Mean	Range	Mean	Range	Geometric (arithmetic) mean efficacy (%)
Study 7	2	26.3 (27.5)	20–44	0.0 (0.0)	0–0	100 (100)	t ₍₆₎ = 24.7, P < 0.0001
	9	13.8 (15.1)	4–23	0.1 (0.1)	0–1	99.3 (99.2)	t ₍₁₄₎ = 13.4, P < 0.000
	16	18.9 (19.6)	12–27	0.3 (0.5)	0–3	98.4 (97.5)	t ₍₆₎ = 9.8, P < 0.0001
	23	27.1 (27.8)	20–38	0.0 (0.0)	0–0	100 (100)	t ₍₆₎ = 37.0, P < 0.0001
	30	21.0 (21.3)	17–28	0.1 (0.1)	0–1	99.6 (99.4)	t ₍₁₄₎ = 28.6, P < 0.0001
	37	27.0 (28.0)	14–38	0.2 (0.3)	0–1	99.3 (99.1)	t ₍₆₎ = 18.5, P < 0.0001
Study 8	2	18.4 (18.6)	14–24	0.0 (0.0)	0–0	100 (100)	t ₍₇₎ = 51.0, P < 0.0001
	9	14.6 (15.0)	9–21	0.0 (0.0)	0–0	100 (100)	t ₍₇₎ = 30.4, P < 0.0001
	16	11.8 (12.8)	7–21	0.0 (0.0)	0–0	na	na
	23	13.6 (13.9)	10–19	0.0 (0.0)	0–0	100 (100)	t ₍₇₎ = 37.9, P < 0.0001
	30	10.6 (13.8)	0–20	0.0 (0.0)	0–0	100 (100)	t ₍₇₎ = 6.9, P = 0.0002
	37	14.1 (14.3)	11–17	0.0 (0.0)	0–0	100 (100)	t ₍₇₎ = 55.1, P < 0.0001

Abbreviation: na not applicable because of insufficient infestations in control dogs

ISSN: 1756-3305