Laboratory evaluations of the immediate and sustained effectiveness of lotilaner (Credelio™) against three common species of ticks affecting dogs in Europe

Table 4 Geometric (arithmetic) mean counts of live Dermacentor reticulatus ticks and dead, attached, engorged ticks in Study 2

Tick species	Day	Untreated control		Lotilaner			Comparison
Tick species	Day	Mean	Range	Mean	Range	Efficacy (%)
Dermacentor reticulatus	2	45.6 (45.8)	40–52	0.4 (0.6)	0–2^a	99.0 (98.6)	t ₍₁₄₎ = 18.8, P < 0.0001
	9	34.6 (35.0)	26–42	0.0 (0.0)	0–0	100 (100)	t ₍₁₄₎ = 60.7, P < 0.0001
	16	37.3 (38.0)	23–48	0.2 (0.3)	0–2^b	99.6 (99.3)	t ₍₁₄₎ = 22.5, P < 0.0001
	23	32.7 (33.4)	19–42	0.0 (0.0)	0–0	100 (100)	t ₍₁₄₎ = 42.8, P < 0.0001
	30	29.8 (31.6)	16–48	0.0 (0.0)	0–0	100 (100)	t ₍₁₄₎ = 26.0, P < 0.0001
	37	28.1 (29.3)	15–44	0.0 (0.0)	0–0	100 (100)	t ₍₁₄₎ = 30.6, P < 0.0001

^aOn Day 2, 48 hours post-treatment, ticks on three dogs, all were dead, attached and engorged
^bOn Day 16, a single lotilaner dog was infested. This dog had one live free tick and one dead attached/engorged tick

ISSN: 1756-3305