TY - JOUR AU - Chen, Tingjin AU - Jiang, Hongye AU - Sun, Hengchang AU - Xie, Zhizhi AU - Ren, Pengli AU - Zhao, Lu AU - Dong, Huimin AU - Shi, Mengchen AU - Lv, Zhiyue AU - Wu, Zhongdao AU - Li, Xuerong AU - Yu, Xinbing AU - Huang, Yan AU - Xu, Jin PY - 2017 DA - 2017/11/09 TI - Sequence analysis and characterization of pyruvate kinase from Clonorchis sinensis, a 53.1-kDa homopentamer, implicated immune protective efficacy against clonorchiasis JO - Parasites & Vectors SP - 557 VL - 10 IS - 1 AB - Clonorchis sinensis, the causative agent of clonorchiasis, is classified as one of the most neglected tropical diseases and affects more than 15 million people globally. This hepatobiliary disease is highly associated with cholangiocarcinoma. As key molecules in the infectivity and subsistence of trematodes, glycolytic enzymes have been targets for drug and vaccine development. Clonorchis sinensis pyruvate kinase (CsPK), a crucial glycolytic enzyme, was characterized in this research. SN - 1756-3305 UR - https://doi.org/10.1186/s13071-017-2494-9 DO - 10.1186/s13071-017-2494-9 ID - Chen2017 ER -