Fig. 5
In vivo trypanocidal activity of uvedalin and enhydrin. Mice were infected with 5 × 103 bloodstream trypomastigotes (RA strain) and treated for 5 consecutive days, starting on day 7 pi with 1 mg/kg/day of uvedalin, enhydrin, BNZ or with an equivalent volume of PBS (negative control). a Circulating parasites on the peak of parasitaemia (day 14 pi). b Parasitaemia curve. c Percentage of body weight loss on the peak of parasitaemia (on day 14 pi). d Survival curve during the acute infection period. Results are shown as mean ± SEM and are representative of 3 independent experiments (*P < 0.05, **P < 0.01 vs negative control)