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Table 1 Median ± SD of histopathological changes assessed in sarcoptic mange skin lesions on the different days post--infection

From: Histopathology, microbiology and the inflammatory process associated with Sarcoptes scabiei infection in the Iberian ibex, Capra pyrenaica

 

Healthy

26 dpi

46 dpi

103 s dpi

103 dpi

150 dpi

Epidermis

      

 Mites/burrows1

0.00

1.45 ± 0.82a

3.18 ± 1.25b

0.60 ± 1.57a

3.51 ± 6.18b

1.63 ± 1.68a

 Basal cell hyperplasia/acanthosis2

5.00

15.54 ± 2.54a

12.77 ± 1.8b

9.95 ± 2.88c

13.80 ± 3.93b

12.22 ± 2.60b

 Rete ridges3

0.00

17.08 ± 4.81a

13.10 ± 4.62b

7.40 ± 3.80c

14.40 ± 3.23b

15.01 ± 3.92b

 Spongiotic oedema4

0.00

14.45 ± 3.85a

15.36 ± 3.29a

4.50 ± 3.77c

10.50 ± 3.83b

7.18 ± 5.54b

 Serocellular crusts5

0.00

2.90 ± 0.54a

3.18 ± 0.60a

0.41 ± 0.69b

3.20 ± 1.13a

0.72 ± 0.64b

 Eosinophilic crusts6

0.00

2.81 ± 0.60a

3.27 ± 0.78a

0.61 ± 0.70b

3.30 ± 0.67a

0.90 ± 0.83b

 Exocytosis foci7

0.00

12.82 ± 4.19a

13.81 ± 3.91a

3.50 ± 3.06c

9.10 ± 3.51b

6.10 ± 3.76b

 Apoptosis/necrosis8

0.00

12.27 ± 3.06a

14.54 ± 2.65a

2.90 ± 2.88c

9 ± 3.80b

6.08 ± 5.85b

Dermis

      

 Sebaceous glands

8.00

27.27 ± 3.70a

24.54 ± 3.32a

19.4 ± 6.10b

25.11 ± 6.65a

21.10 ± 3.17b

 Lymphocytes

18.68

45.97 ± 11.85a

44.67 ± 12.14a

29.31 ± 6.48b

34.46 ± 13.40b

31.81 ± 90b

 Eosinophils

0.20

8.49 ± 0.94a

11.40 ± 1.16a

2.02 ± 5.81b

4.23 ± 2.64b

5.14 ± 1.74b

 Mast cells

0.10

6.72 ± 0.69a

8.32 ± 0.92a

1.14 ± 2.24b

3.42 ± 1.14b

2.53 ± 1.29b

 Neutrophils

0.00

3.52 ± 4.48a

4.17 ± 1.76a

0.71 ± 1.27c

2.41 ± 3.39b

2.77 ± 3.62b

 Plasma cells

0.00

0.53 ± 0.24a

0.64 ± 0.11a

0.37 ± 0.24a

0.42 ± 0.23a

0.43 ± 0.55a

  1. 1Number of mites and/or burrows
  2. 2Number of cells layers from the basal lamina to the stratum granulosum
  3. 3Number of rete ridges along the basal lamina
  4. 4Number of cells with hydropic degeneration
  5. 5Areas of transudation
  6. 6Areas of intense eosinophilic infiltration associated with thepresence of mites and/or burrows
  7. 7Number of exocytosis focus of inflammatory cells associated with vasodilation and vascular neoformation
  8. 8Number of cells with hyperchromatosis with karyorrhectic and pyknotic nuclei
  9. Notes: On day 103 post-infection the ibex that showed self limiting clinic process were included separately (included in column 103 s dpi). Values that have different superscript letters (a-c) along the row differ significantly