Fig. 1
From: Leishmania braziliensis SCD6 and RBP42 proteins, two factors with RNA binding capacity
Structure of L. braziliensis SCD6 protein and molecular modeling. a Multiple sequence alignment of SCD6 protein from trypanosomatids and evolutionarily distant organisms. Protein codes: XP_001565722 (L. braziliensis), CAJ04780 (L. major), XP_828147.1 (T. brucei), P45978 (S. cerevisiae), BAF36055 (X. laevis) and NP_056393.2 (H. sapiens). b Tridimensional structure of L. braziliensis SCD6 protein generated by Phyre2. The different domains and boxes present in this protein are indicated in color as follows: Lsm domain in blue, DFDF domain in magenta, the RGG regions in red, FFD Box in green and TFG Box in purple-blue. c An overlay of the structures of the LbSCD6-LSm domain (blue) with the LSm domain of D. melanogaster TraI (magenta, PDB: 2VXE) and LSm domain of H. sapiens Edc3 (cyan, PDB: 2VC8)