| No. of studies | No. of HIV-infected patients | No. of patients with Isospora co-infection | Prevalence of Isospora co-infection (95% CI) (%) | Heterogeneity | Univariate meta-regression | ||
---|---|---|---|---|---|---|---|---|
P-value | I2 (%) | Coefficient (95% CI) (%) | P-value | |||||
Region |  |  |  |  |  |  | 0.21 (-0.07–0.49) | 0.143 |
 Western and central Europe and North America | 6 | 97,721 | 324 | 0.5 (0.2–0.8) | < 0.0001 | 92.8 |  |  |
 Sub-Saharan Africa | 21 | 3995 | 232 | 6.1 (4.5–7.7) | < 0.0001 | 87.0 |  |  |
 Asia and the Pacific | 24 | 2848 | 215 | 7.1 (5.2–9.0) | < 0.0001 | 83.4 |  |  |
 Latin America and the Caribbean | 5 | 922 | 13 | 1.0 (0.3–1.7) | 0.349 | 10.1 |  |  |
 Middle East and North Africa | 2 | 436 | 4 | 0.8 (0.0–2.0) | 0.279 | 14.7 |  |  |
Income level |  |  |  |  |  |  | -0.04 (-0.38–0.30) | 0.806 |
 Low income | 12 | 2230 | 93 | 3.8 (2.2–5.5) | < 0.0001 | 91.9 |  |  |
 Middle income | 39 | 5904 | 366 | 5.8 (4.7–7.0) | < 0.0001 | 86.9 |  |  |
 High income | 7 | 97,788 | 329 | 0.5 (0.2–0.9) | < 0.0001 | 80.0 |  |  |
Patients with diarrhea |  |  |  |  | < 0.0001 |  | -0.43 (-0.72– -0.13) | 0.005 |
 Yes | 15 | 1271 | 112 | 8.3 (5.7–10.9) | < 0.0001 | 66.1 |  |  |
 Mixed | 43 | 104,651 | 676 | 2.0 (1.6–2.4) | < 0.0001 | 90.4 |  |  |
Total | 58 | 105,922 | 788 | 2.5 (2.1–2.9) | < 0.0001 | 89.8 |  |  |