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Fig. 9 | Parasites & Vectors

Fig. 9

From: Selection strategy of phage-displayed immunogens based on an in vitro evaluation of the Th1 response of PBMCs and their potential use as a vaccine against Leishmania infantum infection

Fig. 9

Phage and parasite-specific humoral response before and after infection. BALB/c mice received saline or were immunized with Wild-type (WT), Random, B1 or D11 clones. Thirty days after the last immunization, sera samples were collected (Before). In addition, remaining animals were challenged with L. infantum promastigotes and followed up for 60 days, at which time sera samples were collected (After). The anti-phage and anti-parasite IgG2a and IgG1 isotype antibody levels were obtained, and the ratios between IgG2a and IgG1 results were calculated and are shown here. Bars represent the mean ± standard deviation. ***P < 0.0001 (a statistically significant difference in relation to the saline, WT and Random groups)

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Parasites & Vectors

ISSN: 1756-3305

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