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Fig. 2 | Parasites & Vectors

Fig. 2

From: Fresh insights into the pyrimidine metabolism in the trypanosomatids

Fig. 2

Schematic representation of the oligomeric states of the various enzymes involved in the pyrimidine metabolism of the trypanosomatids. a Enzymes involved in the de novo pyrimidine biosynthesis pathway. b Enzymes involved in salvage pathway for pyrimidines. The bracketed abbreviations are depicting the techniques employed for the estimation of oligomeric state of an enzyme. PDB ID is also mentioned if the crytstal structure of the given enzyme has been solved. Abbreviations: CPSII, carbamoyl-phosphate synthase; ATCase, aspartate carbamoyl transferase; DHOase, dihydroorotase; DHODH, dihydroorotate dehydrogenase; UMPS, uridine monophosphate synthetase; UKase, uridine kinase; UPase, uridine phosphorylase; UPRT, uracil phospho ribosyl transferase; NDPK, nucleoside-diphosphate kinase; dUTPase, deoxyuridine-triphosphatase; DHFR-TS, dihydrofolate reductase-thymidylate synthase; TK, thymidine kinase. Tc, Trypanosoma cruzi; Tb, Trypanosoma brucei; Ld, Leishmania donovani; Lm, Leishmania major; Cl, Crithidia luciliae; GFC, gel filtration chromatography; DLS, dynamic light scattering; CLS, cross linking Studies; ACS, analytical centrifugation studies; GEMMA, gas phase electrophoretic mobility macromolecule/nanoparticle analysis

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