Table 2 Biological pathways (GO terms and KEGG pathways) showing significant enrichment across three between-group comparisons
Comparison (No. of genes) | Principal GO terms | Fold enrichment | Adjusted P-value | Principal KEGG pathways | P-value |
|---|---|---|---|---|---|
DI vs D (n = 2368) | GO:0039692: ssRNA viral replication | 6.93 | 2.23 × 10−2 | hsa04658: Th1 and Th2 cell differentiation | 6.80 × 10−7 |
GO:2,001,185: regulation of CD8+ T-cells | 6.93 | 2.23 × 10−2 | hsa04110: Cell cycle | 4.33 × 10−6 | |
GO:0072643: IFNγ secretion | 5.78 | 2.34 × 10−3 | hsa05203: Viral carcinogenesis | 1.40 × 10−4 | |
GO:0007076: mitotic chromosome condensation | 5.39 | 2.70 × 10−2 | hsa04114: Oocyte meiosis | 2.19 × 10−4 | |
GO:0046633: T-cell proliferation | 5.33 | 2.65 × 10−2 | hsa04612: Antigen processing and presentation | 3.16 × 10−4 | |
GO:0032620: interleukin-17 production | 4.16 | 2.30 × 10−2 | hsa05166: HTLV-I infection | 1.33 × 10−3 | |
GO:1,901,976: regulation of cell cycle | 3.50 | 3.65 × 10−2 | hsa05340: Primary immunodeficiency | 3.12 × 10−03 | |
DI vs N (n = 6371) | GO:0036037: CD8+ T-cell activation | 2.88 | 3.59 × 10−3 | hsa04750: Inflammatory mediator regulation of TRP channels | 1.22 × 10−3 |
GO:0006270: DNA replication initiation | 2.41 | 4.18 × 10−3 | hsa03030: DNA replication | 2.06 × 10−3 | |
GO:0045047: Protein targeting to ER | 2.07 | 1.11 × 10−5 | hsa03040: Spliceosome | 2.06 × 10−3 | |
GO:0019080: Viral gene expression | 1.98 | 4.53 × 10−9 | hsa04612: Antigen processing and presentation | 2.38 × 10−3 | |
GO:0050853: B-cell receptor signalling pathway | 1.83 | 3.19 × 10−2 | hsa04925: Aldosteron synthesis and secretion | 3.02 × 10−3 | |
GO:0048477: oogenesis | 1.74 | 2.60 × 10−2 | hsa04658: Th1 and Th2 cell differentiation | 5.50 × 10−3 | |
GO:0042098: T-cell proliferation | 1.65 | 6.17 × 10−4 | hsa04110: Cell cycle | 5.70 × 10−3 | |
D vs N (n = 1933) | GO:0045047: Protein targeting to ER | 6.59 | 2.41 × 10−20 | hsa03010: Ribosome | 1.18 × 10−11 |
GO:0019083: Viral gene expression | 4.37 | 1.89 × 10−18 | hsa04612: Antigen processing and presentation | 1.34 × 10−3 | |
GO:0042255: ribosome assembly | 3.92 | 9.50 × 10−4 | hsa03030: DNA replication | 2.42 × 10−2 | |
GO:0042254: ribosome biogenesis | 2.50 | 8.99 × 10−8 | hsa03040: Spliceosome | 5.53 × 10−2 | |
GO:0043043: peptide biosynthetic process | 1.92 | 1.37 × 10−6 | hsa05332: Graft-versus-host disease | 5.53 × 10−2 | |
GO:0006396: RNA processing | 1.81 | 2.26 × 10−7 | hsa05416: Viral myocarditis | 8.33 × 10−2 | |
GO:0033365: Protein localization to organelle | 1.63 | 1.62 × 10−4 |  |  |