TY - JOUR AU - Clements, Michelle N. AU - Corstjens, Paul L. A. M. AU - Binder, Sue AU - Campbell, Carl H. AU - de Dood, Claudia J. AU - Fenwick, Alan AU - Harrison, Wendy AU - Kayugi, Donatien AU - King, Charles H. AU - Kornelis, Dieuwke AU - Ndayishimiye, Onesime AU - Ortu, Giuseppina AU - Lamine, Mariama Sani AU - Zivieri, Antonio AU - Colley, Daniel G. AU - van Dam, Govert J. PY - 2018 DA - 2018/02/23 TI - Latent class analysis to evaluate performance of point-of-care CCA for low-intensity Schistosoma mansoni infections in Burundi JO - Parasites & Vectors SP - 111 VL - 11 IS - 1 AB - Kato-Katz examination of stool smears is the field-standard method for detecting Schistosoma mansoni infection. However, Kato-Katz misses many active infections, especially of light intensity. Point-of-care circulating cathodic antigen (CCA) is an alternative field diagnostic that is more sensitive than Kato-Katz when intensity is low, but interpretation of CCA-trace results is unclear. To evaluate trace results, we tested urine and stool specimens from 398 pupils from eight schools in Burundi using four approaches: two in Burundi and two in a laboratory in Leiden, the Netherlands. In Burundi, we used Kato-Katz and point-of-care CCA (CCAB). In Leiden, we repeated the CCA (CCAL) and also used Up-Converting Phosphor Circulating Anodic Antigen (CAA). SN - 1756-3305 UR - https://doi.org/10.1186/s13071-018-2700-4 DO - 10.1186/s13071-018-2700-4 ID - Clements2018 ER -