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Table 3 Presence of fecal S. lupi eggs and DNA based on sugar flotation and high-resolution melt real-time polymerase chain reaction, respectively, in dogs with naturally occurring esophageal spirocercosis treated with Advocate® or doramectin. Dogs number 2, 3, 5, 6, 7 were switched from Advocate® to doramectin treatment on week 12 and dog number 9 was switched from Advocate® to doramectin treatment on week 5

From: Evaluation of a spot-on imidacloprid-moxidectin formulation (Advocate®) for the treatment of naturally occurring esophageal spirocercosis in dogs: a double-blinded, placebo-controlled study

Week/ Dog ID

1

2

3

4

6

8

12

16

20

FF/PCR

FF/PCR

FF/PCR

FF/PCR

FF/PCR

FF/PCR

FF/PCR

FF/PCR

FF/PCR

Advocate® (treatment) group

 1

+/na

+/+

-/+

+/+

-/-

-/-

-/-

-/+

-/-

 2

+/+

+/+

+/+

+/+

+/+

+/+

+/+

-/+

-/-

 3

-/+

+/-

-/+

-/+

-/-

-/-

-/-

-/-

-/-

 4

+/+

-/-

-/-

-/-

-/-

-/-

-/na

-/-

-/-

 5

-/+

-/-

+/-

-/-

-/-

-/-

-/-

-/-

-/-

 6

-/-

-/+

-/-

-/-

-/-

-/-

-/-

-/-

-/-

 7

-/-

-/+

-/-

+/+

+/+

+/+

+/+

-/+

na/-

 8

-/-

-/-

-/+

-/-

-/-

-/-

-/-

-/-

-/-

 9

-/+

+/+

-/+

-/+

-/+

-/-

-/-

-/-

na/-

 10

-/+

-/+

+/+

-/+

-/-

-/-

-/-

na/-

-/-

Doramectin (control) group

 11

+/na

-/+

-/-

-/+

-/-

-/-

-/-

-/-

-/-

 12

-/-

-/-

-/-

-/-

-/-

-/-

-/-

-/-

-/-

 13

-/-

-/-

-/-

-/-

-/-

-/-

-/-

-/-

-/-

 14

-/-

-/-

-/-

-/-

-/-

-/-

-/-

-/-

-/-

 15

na/+

-/-

-/-

-/-

-/-

-/-

-/-

-/-

-/-

 16

+/+

-/-

-/-

-/-

-/-

-/-

-/-

-/-

-/-

 17

-/-

-/+

-/+

-/+

-/-

-/-

-/-

-/-

-/-

 18

na/+

+/+

-/-

+/na

-/-

-/-

-/-

-/-

-/-

 19

-/-

-/-

-/-

-/-

-/-

-/-

-/-

-/-

-/-

 20

-/na

-/-

-/-

-/-

-/-

-/-

-/-

-/-

na/-

  1. Abbreviations: FF sugar fecal floatation, PCR fecal polymerase chain reaction; na not available