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Table 3 Presence of fecal S. lupi eggs and DNA based on sugar flotation and high-resolution melt real-time polymerase chain reaction, respectively, in dogs with naturally occurring esophageal spirocercosis treated with Advocate® or doramectin. Dogs number 2, 3, 5, 6, 7 were switched from Advocate® to doramectin treatment on week 12 and dog number 9 was switched from Advocate® to doramectin treatment on week 5

From: Evaluation of a spot-on imidacloprid-moxidectin formulation (Advocate®) for the treatment of naturally occurring esophageal spirocercosis in dogs: a double-blinded, placebo-controlled study

Week/ Dog ID 1 2 3 4 6 8 12 16 20
FF/PCR FF/PCR FF/PCR FF/PCR FF/PCR FF/PCR FF/PCR FF/PCR FF/PCR
Advocate® (treatment) group
 1 +/na +/+ -/+ +/+ -/- -/- -/- -/+ -/-
 2 +/+ +/+ +/+ +/+ +/+ +/+ +/+ -/+ -/-
 3 -/+ +/- -/+ -/+ -/- -/- -/- -/- -/-
 4 +/+ -/- -/- -/- -/- -/- -/na -/- -/-
 5 -/+ -/- +/- -/- -/- -/- -/- -/- -/-
 6 -/- -/+ -/- -/- -/- -/- -/- -/- -/-
 7 -/- -/+ -/- +/+ +/+ +/+ +/+ -/+ na/-
 8 -/- -/- -/+ -/- -/- -/- -/- -/- -/-
 9 -/+ +/+ -/+ -/+ -/+ -/- -/- -/- na/-
 10 -/+ -/+ +/+ -/+ -/- -/- -/- na/- -/-
Doramectin (control) group
 11 +/na -/+ -/- -/+ -/- -/- -/- -/- -/-
 12 -/- -/- -/- -/- -/- -/- -/- -/- -/-
 13 -/- -/- -/- -/- -/- -/- -/- -/- -/-
 14 -/- -/- -/- -/- -/- -/- -/- -/- -/-
 15 na/+ -/- -/- -/- -/- -/- -/- -/- -/-
 16 +/+ -/- -/- -/- -/- -/- -/- -/- -/-
 17 -/- -/+ -/+ -/+ -/- -/- -/- -/- -/-
 18 na/+ +/+ -/- +/na -/- -/- -/- -/- -/-
 19 -/- -/- -/- -/- -/- -/- -/- -/- -/-
 20 -/na -/- -/- -/- -/- -/- -/- -/- na/-
  1. Abbreviations: FF sugar fecal floatation, PCR fecal polymerase chain reaction; na not available