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Fig. 2 | Parasites & Vectors

Fig. 2

From: Rethinking the extrinsic incubation period of malaria parasites

Fig. 2

Proportion of malaria-infected mosquitoes with sporozoites present in the salivary glands (i.e. becoming infectious) over time following an infectious blood meal. Here the dynamics of EIP are characterized using a logistic model following the approach of Paaijmans et al. [77] and Shapiro et al. [23, 60] (and see also data in Hien et al. [57]). The conventional way of estimating EIP is to measure the time at which sporozoites first appear in salivary glands of infected mosquitoes (approximating the EIP10). However, given EIP is not perfectly synchronized between individual mosquitoes, the EIP could equally be characterized using alternative measures such as the median value for the mosquito population (EIP50), or the time at which the maximum proportion of the population become infectious (approximating the EIP90). In this illustrative example we assume all infected mosquitoes go on to become infectious. If conversion efficiency of oocysts to sporozoites is less than 100%, the asymptote will be reduced

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