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Table 1 Clinical signs, serology and PCR test results recorded in the two orangutans (Pongo pygmaeus pygmaeus) examined in this study

From: First report of Leishmania infantum infection in the endangered orangutan (Pongo pygmaeus pygmaeus) in Madrid, Spain

Animal description Case 1, male, 36 years Case 2, female, 34 years
Dates of screening December 2016 (before diagnosis) March 2017 (diagnosis) July 2017 (after treatment) June 2017 (diagnosis) October 2017 (after treatment)
Clinical signs Weight loss, apathy, hepato-splenomegaly Weight loss, apathy, hepato-splenomegaly, bilateral epistaxis Hepatomegaly Weight loss, apathy, splenomegaly, pericardial effusion No signs, no weight gain
CBC [reference values (ZIMS)]
Red blood count (3.62–5.89) ×1012/l 2.84 2.78 4.68 2.18 3.09
Haematocrit (29.0–44.9) % 25.1 21.1 41.8 16.3 20.3
Haemoglobin (8.9–13.9) g/dl 7.5 6.2 11.5 4.1 5.4
White blood count (3.8–17) ×109/l 3.2 2.0 8.1 0.538 0.42
Platelets (84–309) × 109/l 101 60 142 77.5 76.3
BP [reference values (ZIMS)]  
Albumin (3.0–5.2) g/dl 2.4 2.1 2.7 2.1 2.4
ALT (6–43) U/L 51 76 41 17 20
AST (4–33) U/L 66 106 33 18 37
Serology results (IFAT) 1/200 1/400 1/200 1/400 1/200
Bone marrow cytology (microscopy) nt POS NEG POS NEG
PCR results  
Peripheral blood POS POS nt POS POS
Bone marrow nt nt POS POS POS
  1. Abbreviations: CBC complete blood counts, BP biochemical profile, POS positive, NEG negative, nt not tested, IFAT immunofluorescence antibody test, ZIMS Species 360 (Zoological Information Management System 2017) [43]