Comparative effectiveness of malaria prevention measures: a systematic review and network meta-analysis

Parasites & Vectors

Table 2 Direct, indirect and final results from comparison of different preventive measures

ID	Comparison	Active	Control	RR	95% LCI	95% HCI	K ^a	H
Direct estimates
1	UN-PD	UN	PD	0.12	0.01	0.94	1	1
2	ITN-UN	ITN	UN	0.56	0.40	0.76	4	1.11
3	ITN-NI	ITN	NI	0.57	0.41	0.81	10	2.76
4	PD-NI	PD	NI	0.21	0.13	0.33	10	2.49
5	IRS-NI	IRS	NI	0.55	0.20	1.56	3	3.41
6	UN-NI	UN	NI	0.67	0.49	0.92	2	1
Indirect estimates (source IDs)
7	Indirect UN vs NI (1, 4)	UN	NI	0.02	0.003	0.21	2	3.01
8	Indirect ITN vs NI (2, 6)	ITN	NI	0.37	0.24	0.58	2	1.85
9	Indirect PD vs NI (1, 6)	PD	NI	5.70	0.70	46.58	2	3.01
10	Indirect UN vs NI (2, 3)	UN	NI	1.03	0.64	1.66	2	1.85
Final estimates from all evidence (source IDs)
	PD (4, 9)	PD	NI	0.24	0.004	15.43	2	3.00
	ITN (3, 8)	ITN	NI	0.49	0.32	0.74	2	1.85
	IRS (5)	IRS	NI	0.55	0.20	1.56	1	1
	UN (6, 7, 10)	UN	NI	0.73	0.28	1.90	3	2.59
Network H = 2.21

Abbreviations: ITC insecticide-treated curtain, ITN insecticide-treated net, PD prophylactic drug, NI no intervention, IRS indoor residual spraying, UN untreated nets, RR rate ratio, LCI lower confidence interval, HCI higher confidence interval
^aNumber of studies

ISSN: 1756-3305