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Table 1 Trial 1 results from the negative binomial mixed model that included treatment group, sample day and their interaction as fixed effects and dog as random effect. Results are presented as the incidence rate ratio (IRR) which is the increase in the rate of incidence compared with control at each sampling day

From: Phlebotomine mortality effect of systemic insecticides administered to dogs

Covariates effecta IRRb 95% CI P-value
Day 2: Control Reference
Afoxolaner 1.39 0.74–2.67 0.31
Fluralaner 1.94 1.14–3.39 0.01*
Moxidectin 0.60 0.26–1.29 0.21
Spinosad 0.90 0.43–1.80 0.77
Day 4: Control Reference
Afoxolaner 1.34 0.82–2.18 0.23
Fluralaner 1.68 1.05–2.71 0.03*
Moxidectin 0.77 0.45–1.31 0.34
Spinosad 1.02 0.61–1.70 0.92
Day 21: Control Reference
Afoxolaner 1.11 0.67–1.89 0.67
Fluralaner 0.81 0.47–1.38 0.45
Moxidectin 0.91 0.54–1.53 0.73
Spinosad 0.96 0.57–1.61 0.89
Day 31: Control Reference
Afoxolaner 1.51 0.81–2.89 0.20
Fluralaner 1.21 0.64–2.31 0.55
Moxidectin 1.33 0.65–2.74 0.41
Spinosad 1.41 0.77–2.66 0.27
  1. aThe covariate effects used control group at each corresponding day after treatment as baseline comparison [Pr(>|z|)]
  2. bIncidence rate ratio, as the ratio between the incidence rate in control group and the incidence rate for each treatment group, at the corresponding sampling day after treatment
  3. *Significance level defined at α = 0.05