Phlebotomine mortality effect of systemic insecticides administered to dogs

Parasites & Vectors

Table 2 Trial 1 results from the cox proportional hazard model that included treatment group, sample day and their interaction as fixed effects and dog as random effect. Results are presented as the hazard rate ratio (HRR) which is the increase in the hazard rate compared with control at each sampling day

Covariates effect^a	HRR^b	95% CI	P-value
Day 2: Control	Reference	–	–
Afoxolaner	1.13	0.85–1.56	0.45
Fluralaner	1.47	1.10–1.96	< 0.001*
Moxidectin	0.73	0.51–1.01	0.06
Spinosad	0.76	0.54–1.08	0.08
Day 4: Control	Reference	–	–
Afoxolaner	1.25	0.93–1.67	0.08
Fluralaner	1.83	1.36–2.45	< 0.001*
Moxidectin	0.84	0.62–1.13	0.17
Spinosad	0.74	0.53–1.02	0.33
Day 21: Control	Reference	–	–
Afoxolaner	1.39	0.98–1.86	0.07
Fluralaner	0.96	0.72–1.28	0.91
Moxidectin	1.06	0.78–1.39	0.55
Spinosad	1.04	0.76–1.38	0.61
Day 31: Control	Reference	–	–
Afoxolaner	1.42	0.99–1.93	0.08
Fluralaner	1.25	0.93–1.68	0.43
Moxidectin	1.12	0.65–1.64	0.57
Spinosad	0.99	0.73–1.32	0.37

^aThe covariate effects used control group at each corresponding day after treatment as baseline comparison [Pr(>|z|)]
^bHazard rate ratio, as the ratio between the hazard rate in control group and the hazard rate for each treatment group, at the corresponding sampling day after treatment
^*Significance level defined at α = 0.05

ISSN: 1756-3305