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Table 2 Trial 1 results from the cox proportional hazard model that included treatment group, sample day and their interaction as fixed effects and dog as random effect. Results are presented as the hazard rate ratio (HRR) which is the increase in the hazard rate compared with control at each sampling day

From: Phlebotomine mortality effect of systemic insecticides administered to dogs

Covariates effecta HRRb 95% CI P-value
Day 2: Control Reference
Afoxolaner 1.13 0.85–1.56 0.45
Fluralaner 1.47 1.10–1.96 < 0.001*
Moxidectin 0.73 0.51–1.01 0.06
Spinosad 0.76 0.54–1.08 0.08
Day 4: Control Reference
Afoxolaner 1.25 0.93–1.67 0.08
Fluralaner 1.83 1.36–2.45 < 0.001*
Moxidectin 0.84 0.62–1.13 0.17
Spinosad 0.74 0.53–1.02 0.33
Day 21: Control Reference
Afoxolaner 1.39 0.98–1.86 0.07
Fluralaner 0.96 0.72–1.28 0.91
Moxidectin 1.06 0.78–1.39 0.55
Spinosad 1.04 0.76–1.38 0.61
Day 31: Control Reference
Afoxolaner 1.42 0.99–1.93 0.08
Fluralaner 1.25 0.93–1.68 0.43
Moxidectin 1.12 0.65–1.64 0.57
Spinosad 0.99 0.73–1.32 0.37
  1. aThe covariate effects used control group at each corresponding day after treatment as baseline comparison [Pr(>|z|)]
  2. bHazard rate ratio, as the ratio between the hazard rate in control group and the hazard rate for each treatment group, at the corresponding sampling day after treatment
  3. *Significance level defined at α = 0.05