Table 4 Trial 2 results from the Cox proportional hazard model that included treatment group, sample day and their interaction as fixed effects and dog as random effect. Results are presented as the hazard rate ratio (HRR) which is the increase in the hazard rate compared with control at each sampling day

Day 2: Control

Reference

–

–

Fluralaner

0.97

0.70–1.36

0.90

Day 4: Control

Reference

–

–

Fluralaner

1.12

0.70–1.53

0.43

Day 7: Control

Reference

–

–

Fluralaner

1.27

0.94–1.72

0.12

Day 14: Control

Reference

–

–

Fluralaner

1.92

1.40–2.64

<0.0001*

Day 18: Control

Reference

–

–

Fluralaner

1.15

0.84–1.59

0.36

Day 32: Control

Reference

–

–

Fluralaner

1.28

0.94–1.75

0.10

Day 39: Control

Reference

–

–

Fluralaner

0.86

0.65–1.15

0.33

Day 51: Control

Reference

–

–

Fluralaner

0.86

0.64–1.15

0.22

Day 84: Control

Reference

–

–

Fluralaner

0.73

0.53–1.05

0.09