Table 2 Evaluation of patient characteristics, opportunistic pathogen shedding, and fecal S100A12 concentrations in dogs included in this study (n = 307). P-values in bold font indicate a significant effect (P < 0.05)
Patient parameter or enteropathogen status | n | Fecal S100A12 concentration, median (IQR) (ng/g) | Fecal S100A12 above RI, n (%) | P (univariate analysis) | P (multivariate analysis) | |||
|---|---|---|---|---|---|---|---|---|
Individual pathogensd | Individual pathogense | Groups of pathogens | All entero-pathogens | |||||
Fecal score interpretation | ||||||||
Abnormala | 75 | 118 (24–579) | 14 (19) | < 0.0001 (Z = 5.749) | < 0.0001 (F(1, 251) = 18.832) | < 0.0001 (F(1, 250) = 17.897) | < 0.0001 (F(1, 268) = 23.418) | < 0.0001 (F(1, 267) = 22.690) |
Normal | 223 | 24 (24–56) | 6 (3) | |||||
Age | ||||||||
4–6 weeks | 142 | 24 (24–136) | 8 (6) | 0.5025 (χ2 = 1.377, df = 2) | ns | ns | ns | ns |
7–9 weeks | 138 | 24 (24–95) | 11 (8) | |||||
≥10 weeks | 27 | 24 (24–44) | 1 (4) | |||||
Sex | ||||||||
Female | 152 | 24 (24–150) | 15 (10) | 0.1670 (Z = -1.382) | 0.5056 (F(1, 234 = 0.445) | 0.4730 (F(1, 231) = 0.517) | 0.3683 (F(1, 239) = 0.812) | 0.4047 (F(1, 243) = 0.697) |
Male | 126 | 24 (24–95) | 5 (4) | |||||
Breed size | ||||||||
Small breedb | 78 | 74 (24–633) | 16 (21) | < 0.0001 (Z = 4.879) | 0.0013 (F(1, 52) = 11.562) | 0.0012 (F(1, 53) = 11.733) | 0.0019 (F(1, 53) = 11.655) | 0.0007 (F(1, 52) = 13.127) |
Large breedc | 229 | 24 (24–67) | 7 (3) | |||||
Toxocara canis | ||||||||
Shedding | 63 | 24 (24–168) | 6 (10) | 0.3565 (Z = 0.922) | ns | ns | – | – |
No shedding | 238 | 24 (24–91) | 12 (5) | |||||
Cystoisospora spp. | ||||||||
Shedding | 117 | 24 (24–153) | 9 (8) | 0.0384 (Z = 2.070) | 0.2014 (F(1, 96) = 1.655) | – | – | – |
No shedding | 184 | 24 (24–78) | 9 (5) | |||||
Cystoisospora canis | ||||||||
Shedding | 38 | 24 (24–223) | 2 (5) | 0.1668 (Z = 1.382) | – | 0.1288 (F(1, 90) = 2.350) | – | – |
No shedding | 263 | 24 (24–86) | 16 (6) | |||||
Cystoisospora ohioensis | ||||||||
Shedding | 84 | 24 (24–112) | 8 (10) | 0.2790 (Z = 1.083) | – | ns | – | – |
No shedding | 217 | 24 (24–101) | 10 (5) | |||||
Giardia spp. | ||||||||
Shedding | 126 | 24 (24–176) | 7 (6) | 0.5450 (Z = 0.605) | ns | ns | – | – |
No shedding | 179 | 24 (24–94) | 13 (7) | |||||
At least 1 parasite | ||||||||
Shedding | 222 | 24 (24–126) | 14 (6) | 0.3686 (Z = -0.899) | – | – | ns | – |
No shedding | 85 | 24 (24–87) | 6 (7) | |||||
CCV | ||||||||
Infected | 61 | 24 (24–38) | 5 (8) | 0.0345 (Z = -2.115) | 0.4505 (F(1, 63) = 0.577) | 0.4935 (F(1, 66) = 0.474) | – | – |
Not infected | 242 | 24 (24–141) | 15 (6) | |||||
CPV2 | ||||||||
Infected | 54 | 32 (24–283) | 5 (9) | 0.0277 (Z = 2.202) | 0.8138 (F(1, 77) = 0.056) | 0.8870 (F(1, 77) = 0.020) | – | – |
Not infected | 247 | 24 (24–90) | 15 (6) | |||||
At least 1 virus | ||||||||
Infected | 114 | 24 (24–120) | 10 (9) | 0.9090 (Z = 0.114) | – | – | ns | – |
Not infected | 188 | 24 (24–127) | 10 (5) | |||||
At least 1 enteropathogen | ||||||||
Shedding/infected | 237 | 24 (24–138) | 19 (8) | 0.0881 (Z = -1.705) | – | – | – | 0.2398 (F(1, 86) = 1.401) |
No shedding/not infected | 70 | 24 (24–60) | 1 (1) | |||||